| Host: |
Rabbit |
| Applications: |
WB/IHC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Exonuclease 3 5 Domain-Containing Protein 2 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: |
Antigen affinity purification |
| Concentration: |
0.96 mg/mL |
| Dilution Range: |
WB 1:500-1:2000, IHC 1:40-1:200 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: |
EXD2 |
| Gene ID: |
55218 |
| Uniprot ID: |
EXD2_HUMAN |
| Immunogen: |
Fusion protein of human EXD2 |
| Function | Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation. |
| Protein Name | Exonuclease 3'-5' Domain-Containing Protein 23'-5' Exoribonuclease Exd2Exonuclease 3'-5' Domain-Like-Containing Protein 2 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinMitochondrion MatrixNucleusChromosomeMainly Localizes To The Mitochondrial Outer MembraneMay Translocate To The Nucleus In Response To Dna DamageHowever Mechanism That Explain Nuclear Localization Are Unknown And Require Experimental EvidencesRecruited To Replication Forks Following Replication Stress |
| Alternative Antibody Names | Anti-Exonuclease 3'-5' Domain-Containing Protein 2 antibodyAnti-3'-5' Exoribonuclease Exd2 antibodyAnti-Exonuclease 3'-5' Domain-Like-Containing Protein 2 antibodyAnti-EXD2 antibodyAnti-C14orf114 antibodyAnti-EXDL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
