Anti-EXD2 antibody (STJA0004825)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human EXD2
General Information
| Short Description | Rabbit polyclonal anti-Exonuclease 3 5 Domain-Containing Protein 2 for use in WB, IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.96 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | WB 1:500-1:2000, IHC 1:40-1:200 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | EXD2 |
| Gene ID | 55218 |
| Uniprot ID | EXD2_HUMAN |
| Immunogen | Fusion protein of human EXD2 |
Additional Info
| Function | Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation. |
| Protein Name | Exonuclease 3'-5' Domain-Containing Protein 23'-5' Exoribonuclease Exd2Exonuclease 3'-5' Domain-Like-Containing Protein 2 |
| Database Links | |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinMitochondrion MatrixNucleusChromosomeMainly Localizes To The Mitochondrial Outer MembraneMay Translocate To The Nucleus In Response To Dna DamageHowever Mechanism That Explain Nuclear Localization Are Unknown And Require Experimental EvidencesRecruited To Replication Forks Following Replication Stress |
| Alternative Antibody Names | Anti-Exonuclease 3'-5' Domain-Containing Protein 2 antibodyAnti-3'-5' Exoribonuclease Exd2 antibodyAnti-Exonuclease 3'-5' Domain-Like-Containing Protein 2 antibodyAnti-EXD2 antibodyAnti-C14orf114 antibodyAnti-EXDL2 antibody |
Information sourced from Uniprot.org