| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ETV6 (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ETV6 |
| Gene ID: |
2120 |
| Uniprot ID: |
ETV6_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1). |
| Immunogen Sequence: |
MSETPAQCSIKQERISYTPP ESPVPSYASSTPLHVPVPRA LRMEEDSIRLPAHLRLQPIY WSRDDVAQWLKWAENEFSLR PIDSNTFEMNGKALLLLTKE DFRYRSPHSGDVLYELLQHI LKQRKPRILFSPFFHPGNSI HTQPEVILHQNHEEDNCVQR TPRPSVDNVHHNPPTIELLH RSRSPITTNHRPSPDPEQRP LRSPLDNMIRRLSPAERAQG PRPHQENNHQESYPLSVSP |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression. |
| Function | Transcriptional repressor.binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. |
| Protein Name | Transcription Factor Etv6Ets Translocation Variant 6Ets-Related Protein Tel1Tel |
| Database Links | Reactome: R-HSA-9673768Reactome: R-HSA-9703465 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Etv6 antibodyAnti-Ets Translocation Variant 6 antibodyAnti-Ets-Related Protein Tel1 antibodyAnti-Tel antibodyAnti-ETV6 antibodyAnti-TEL antibodyAnti-TEL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
