| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ETV4 (40-484) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ETV4 |
| Gene ID: |
2118 |
| Uniprot ID: |
ETV4_HUMAN |
| Immunogen Region: |
40-484 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-484 of human ETV4 (NP_001977.1). |
| Immunogen Sequence: |
MDPGSLPPLDSEDLFQDLSH FQETWLAEAQVPDSDEQFVP DFHSENLAFHSPTTRIKKEP QSPRTDPALSCSRKPPLPYH HGEQCLYSSAYDPPRQIAIK SPAPGALGQSPLQPFPRAEQ RNFLRSSGTSQPHPGHGYLG EHSSVFQQPLDICHSFTSQG GGREPLPAPYQHQLSEPCPP YPQQSFKQEYHDPLYEQAGQ PAVDQGG |
| Tissue Specificity | Expressed in keratinocytes. |
| Post Translational Modifications | Sumoylated.enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2. |
| Function | Transcriptional activator. May play a role in keratinocyte differentiation. (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator.the core-binding sequence is 5'-ACGGAATGT-3'. |
| Protein Name | Ets Translocation Variant 4Adenovirus E1a Enhancer-Binding ProteinE1a-FPolyomavirus Enhancer Activator 3 HomologProtein Pea3 |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ets Translocation Variant 4 antibodyAnti-Adenovirus E1a Enhancer-Binding Protein antibodyAnti-E1a-F antibodyAnti-Polyomavirus Enhancer Activator 3 Homolog antibodyAnti-Protein Pea3 antibodyAnti-ETV4 antibodyAnti-E1AF antibodyAnti-PEA3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
