Anti-ETHE1 antibody (STJA0009521)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ETHE1
General Information
| Short Description | Rabbit polyclonal anti-Persulfide dioxygenase ETHE1, mitochondrial for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ETHE1 |
| Gene ID | 23474 |
| Uniprot ID | ETHE1_HUMAN |
| Immunogen | Synthesized peptide derived from human ETHE1 |
| Specificity | This antibody detects endogenous levels of ETHE1 at Human, Mouse |
Additional Info
| Function | Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus. |
| Protein Name | Persulfide Dioxygenase Ethe1 - MitochondrialEthylmalonic Encephalopathy Protein 1Hepatoma Subtracted Clone One ProteinSulfur Dioxygenase Ethe1 |
| Database Links | Reactome: R-HSA-1614517 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Matrix |
| Alternative Antibody Names | Anti-Persulfide Dioxygenase Ethe1 - Mitochondrial antibodyAnti-Ethylmalonic Encephalopathy Protein 1 antibodyAnti-Hepatoma Subtracted Clone One Protein antibodyAnti-Sulfur Dioxygenase Ethe1 antibodyAnti-ETHE1 antibodyAnti-HSCO antibody |
Information sourced from Uniprot.org