Anti-ETAA1 antibody [R03-8J1] (STJA0034292)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human ETAA1
General Information
| Short Description | Rabbit monoclonal anti-ETAA1 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-8J1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ETAA1 |
| Gene ID | 54465 |
| Uniprot ID | ETAA1_HUMAN |
| Immunogen | Recombinant protein of human ETAA1 |
Additional Info
| Tissue Specificity | Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines. |
| Post Translational Modifications | Phosphorylated by ATR. |
| Function | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. |
| Protein Name | Ewing's Tumor-Associated Antigen 1Ewing's Tumor-Associated Antigen 16 |
| Database Links | |
| Cellular Localisation | NucleusLocalizes At Sites Of Dna Damage Following Replication StressRecruited To Stalled Replication Forks Via Interaction With Rpa1 And Rpa2 Subunits Of The Rpa Complex |
| Alternative Antibody Names | Anti-Ewing's Tumor-Associated Antigen 1 antibodyAnti-Ewing's Tumor-Associated Antigen 16 antibodyAnti-ETAA1 antibodyAnti-ETAA16 antibody |
Information sourced from Uniprot.org