| Tissue Specificity | Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines. |
| Post Translational Modifications | Phosphorylated by ATR. |
| Function | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. |
| Protein Name | Ewing's Tumor-Associated Antigen 1Ewing's Tumor-Associated Antigen 16 |
| Database Links | |
| Cellular Localisation | NucleusLocalizes At Sites Of Dna Damage Following Replication StressRecruited To Stalled Replication Forks Via Interaction With Rpa1 And Rpa2 Subunits Of The Rpa Complex |
| Alternative Antibody Names | Anti-Ewing's Tumor-Associated Antigen 1 antibodyAnti-Ewing's Tumor-Associated Antigen 16 antibodyAnti-ETAA1 antibodyAnti-ETAA16 antibody |
Information sourced from Uniprot.org
