Anti-ESYT1 antibody (Internal) (STJ71456)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ESYT1 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.IHC: Paraffin embedded Human Placenta. Recommended concentration: 3.75ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ESYT1 |
| Gene ID | 23344 |
| Uniprot ID | ESYT1_HUMAN |
| Accession Number | NP_056107.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | QKKRTLSPEFNER |
Additional Info
| Post Translational Modifications | Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro).this promotes interaction with SLC2A4. |
| Function | Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. |
| Protein Name | Extended Synaptotagmin-1E-Syt1Membrane-Bound C2 Domain-Containing Protein |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9035034Reactome: R-HSA-9845576 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell MembranePeripheral Membrane ProteinLocalizes Primarily To The Endoplasmic ReticulumRecruited To Sites Of Contact Between The Endoplasmic Reticulum And The Cell Membrane In Response To Increased Cytosolic Calcium Levels |
| Alternative Antibody Names | Anti-Extended Synaptotagmin-1 antibodyAnti-E-Syt1 antibodyAnti-Membrane-Bound C2 Domain-Containing Protein antibodyAnti-ESYT1 antibodyAnti-FAM62A antibodyAnti-KIAA0747 antibodyAnti-MBC2 antibody |
Information sourced from Uniprot.org