| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ESYT1 (90-220) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ESYT1 |
| Gene ID: |
23344 |
| Uniprot ID: |
ESYT1_HUMAN |
| Immunogen Region: |
90-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 90-220 of human ESYT1 (NP_056107.1). |
| Immunogen Sequence: |
GWRRVRDEKERSLRAARQLL DDEEQLTAKTLYMSHRELPA WVSFPDVEKAEWLNKIVAQV WPFLGQYMEKLLAETVAPAV RGSNPHLQTFTFTRVELGEK PLRIIGVKVHPGQRKEQILL DLNISYVGDVQ |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro).this promotes interaction with SLC2A4. |
| Function | Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. |
| Protein Name | Extended Synaptotagmin-1E-Syt1Membrane-Bound C2 Domain-Containing Protein |
| Database Links | Reactome: R-HSA-1660662Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9035034 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell MembranePeripheral Membrane ProteinLocalizes Primarily To The Endoplasmic ReticulumRecruited To Sites Of Contact Between The Endoplasmic Reticulum And The Cell Membrane In Response To Increased Cytosolic Calcium Levels |
| Alternative Antibody Names | Anti-Extended Synaptotagmin-1 antibodyAnti-E-Syt1 antibodyAnti-Membrane-Bound C2 Domain-Containing Protein antibodyAnti-ESYT1 antibodyAnti-FAM62A antibodyAnti-KIAA0747 antibodyAnti-MBC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
