Anti-ESX1 antibody (327-377 aa) (STJ194012)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ESX1 at the amino acid range 327-377
General Information
| Short Description | Rabbit polyclonal anti-Homeobox protein ESX1 (327-377 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ESX1 |
| Gene ID | 80712 |
| Uniprot ID | ESX1_HUMAN |
| Immunogen | Synthesized peptide derived from the human ESX1 at the amino acid range 327-377 |
| Immunogen Region | 327-377 aa |
| Specificity | This antibody detects endogenous levels of ESX1 at Human |
Additional Info
| Post Translational Modifications | Undergoes proteolytic cleavage.produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20 kDa C-terminal fragment (ESXR1-C). |
| Function | May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. |
| Protein Name | Homeobox Protein Esx1Extraembryonic - Spermatogenesis - Homeobox 1 Cleaved Into - Homeobox Protein Esx1-N - Homeobox Protein Esx1-C |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusEsxr1-N Localizes Specifically To The Nucleus While Esxr1-C Localizes Specifically To The Cytoplasm |
| Alternative Antibody Names | Anti-Homeobox Protein Esx1 antibodyAnti-Extraembryonic - Spermatogenesis - Homeobox 1 Cleaved Into - Homeobox Protein Esx1-N - Homeobox Protein Esx1-C antibodyAnti-ESX1 antibodyAnti-ESX1L antibodyAnti-ESX1R antibody |
Information sourced from Uniprot.org