| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Homeobox protein ESX1 (327-377 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ESX1 |
| Gene ID: |
80712 |
| Uniprot ID: |
ESX1_HUMAN |
| Immunogen Region: |
327-377 aa |
| Specificity: |
This antibody detects endogenous levels of ESX1 at Human |
| Immunogen: |
Synthesized peptide derived from the human ESX1 at the amino acid range 327-377 |
| Post Translational Modifications | Undergoes proteolytic cleavage.produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20 kDa C-terminal fragment (ESXR1-C). |
| Function | May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. |
| Protein Name | Homeobox Protein Esx1Extraembryonic - Spermatogenesis - Homeobox 1 Cleaved Into - Homeobox Protein Esx1-N - Homeobox Protein Esx1-C |
| Cellular Localisation | CytoplasmNucleusEsxr1-N Localizes Specifically To The Nucleus While Esxr1-C Localizes Specifically To The Cytoplasm |
| Alternative Antibody Names | Anti-Homeobox Protein Esx1 antibodyAnti-Extraembryonic - Spermatogenesis - Homeobox 1 Cleaved Into - Homeobox Protein Esx1-N - Homeobox Protein Esx1-C antibodyAnti-ESX1 antibodyAnti-ESX1L antibodyAnti-ESX1R antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
