Anti-Estrogen Receptor antibody [ZR2] (STJ16101842)

SKU:
STJ16101842-1

£1,925.50
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Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Estrogen Receptor is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: ZR2
Conjugation: Unconjugated
Isotype: IgG
Formulation: Tissue culture supernatant with 0.2% BSA and 15mM sodium azide
Purification: Concentrate
Dilution Range: IHC-P 1:300
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: A synthetic peptide corresponding to residues on the C-terminus of human ER-Alpha
Background Recognizes a protein of 67kDa, which is identified as estrogen receptor (ER) alpha. The ER gene consists of more than 140kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally discrete domains, labeled A through F. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to antiestrogen (e.g. tamoxifen) therapy. Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer, pH6.0, or in 50 mM Tris buffer pH9.5, for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections. Note: Dilution of the antibody in 10% normal goat serum followed by a goat anti-rabbit secondary antibody-based detection is recommended. Control tissue Breast carcinoma. Staining nuclear.

Information sourced from Uniprot.org

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