| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Epithelial splicing regulatory protein 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ESRP1 |
| Gene ID: |
54845 |
| Uniprot ID: |
ESRP1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of ESRP1 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human ESRP1 |
| Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium. |
| Protein Name | Epithelial Splicing Regulatory Protein 1Rna-Binding Motif Protein 35aRna-Binding Protein 35a |
| Database Links | Reactome: R-HSA-6802952Reactome: R-HSA-6803529 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Epithelial Splicing Regulatory Protein 1 antibodyAnti-Rna-Binding Motif Protein 35a antibodyAnti-Rna-Binding Protein 35a antibodyAnti-ESRP1 antibodyAnti-RBM35A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
