Anti-ERVW-1 antibody (442-492) (STJA0006658)

SKU:
STJA0006658

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Syncytin-1 (442-492) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ERVW-1
Gene ID: 30816
Uniprot ID: SYCY1_HUMAN
Immunogen Region: 442-492
Specificity: This antibody detects endogenous levels of human ENW1
Immunogen: Synthesized peptide derived from human ENW1 AA range: 442-492
Post Translational Modifications Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as an inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence KR-X-KR-R. The intracytoplasmic tail cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope proteins seems to have been lost during evolution. The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.
Function This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.
Protein Name Syncytin-1
Endogenous Retrovirus Group W Member 1
Env-W
Envelope Polyprotein Gpr73
Enverin
Herv-7q Envelope Protein
Herv-W Envelope Protein
Herv-W_7q21.2 Provirus Ancestral Env Polyprotein
Syncytin Cleaved Into - Surface Protein
Su
Gp50 - Transmembrane Protein
Tm
Gp24
Cellular Localisation Surface Protein: Cell Membrane
Peripheral Membrane Protein
The Surface Protein Is Not Anchored To The Membrane
But Localizes To The Extracellular Surface Through Its Binding To Tm
Transmembrane Protein: Cell Membrane
Single-Pass Type I Membrane Protein
Syncytin-1: Virion
Alternative Antibody Names Anti-Syncytin-1 antibody
Anti-Endogenous Retrovirus Group W Member 1 antibody
Anti-Env-W antibody
Anti-Envelope Polyprotein Gpr73 antibody
Anti-Enverin antibody
Anti-Herv-7q Envelope Protein antibody
Anti-Herv-W Envelope Protein antibody
Anti-Herv-W_7q21.2 Provirus Ancestral Env Polyprotein antibody
Anti-Syncytin Cleaved Into - Surface Protein antibody
Anti-Su antibody
Anti-Gp50 - Transmembrane Protein antibody
Anti-Tm antibody
Anti-Gp24 antibody
Anti-ERVW-1 antibody
Anti-ERVWE1 antibody

Information sourced from Uniprot.org

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