Anti-ERO1A antibody (STJA0007416)

SKU:
STJA0007416

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ERO1-like protein alpha is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ERO1A
Gene ID: 30001
Uniprot ID: ERO1A_HUMAN
Specificity: This antibody detects endogenous levels of ERO1L at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human ERO1L
Post Translational Modifications N-glycosylated. The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397. The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-131. Phosphorylated on Ser-145 by FAM20C in the Golgi which increases its enzymatic activity. Phosphorylation is induced by lactation. It is also induced by hypoxia and reductive stress.
Function Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin.
Protein Name Ero1-Like Protein Alpha
Ero1-L
Ero1-L-Alpha
Endoplasmic Oxidoreductin-1-Like Protein
Endoplasmic Reticulum Oxidoreductase Alpha
Oxidoreductin-1-L-Alpha
Database Links Reactome: R-HSA-3299685
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Lumenal Side
Golgi Apparatus Lumen
Secreted
Cell Projection
Dendrite
The Association With Erp44 Is Essential For Its Retention In The Endoplasmic Reticulum
In Neurons
It Localizes To Dendrites
Alternative Antibody Names Anti-Ero1-Like Protein Alpha antibody
Anti-Ero1-L antibody
Anti-Ero1-L-Alpha antibody
Anti-Endoplasmic Oxidoreductin-1-Like Protein antibody
Anti-Endoplasmic Reticulum Oxidoreductase Alpha antibody
Anti-Oxidoreductin-1-L-Alpha antibody
Anti-ERO1A antibody
Anti-ERO1L antibody
Anti-UNQ434 antibody
Anti-PRO865 antibody

Information sourced from Uniprot.org

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