Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-EREG (C-Term) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | EREG |
Gene ID: | 2069 |
Uniprot ID: | EREG_HUMAN |
Immunogen Region: | C-Term |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human EREG (NP_001423.1). |
Immunogen Sequence: | GVRCEHFFLTVHQPLSKEYV ALTVILIILFLITVVGSTYY FCRWYRNRKSKEPKKEYERV TSGDPELPQV |
Tissue Specificity | In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. |
Function | Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. |
Protein Name | Proepiregulin Cleaved Into - Epiregulin Epr |
Database Links | Reactome: R-HSA-1227986 Reactome: R-HSA-1236394 Reactome: R-HSA-1250196 Reactome: R-HSA-1250342 Reactome: R-HSA-1250347 Reactome: R-HSA-1251985 Reactome: R-HSA-1257604 Reactome: R-HSA-177929 Reactome: R-HSA-179812 Reactome: R-HSA-180292 Reactome: R-HSA-180336 Reactome: R-HSA-182971 Reactome: R-HSA-1963640 Reactome: R-HSA-1963642 Reactome: R-HSA-212718 Reactome: R-HSA-2219530 Reactome: R-HSA-5638303 Reactome: R-HSA-5673001 Reactome: R-HSA-6785631 Reactome: R-HSA-6811558 Reactome: R-HSA-8847993 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-8863795 Reactome: R-HSA-9009391 Reactome: R-HSA-9634638 Reactome: R-HSA-9664565 Reactome: R-HSA-9665686 |
Cellular Localisation | Epiregulin: Secreted Extracellular Space Proepiregulin: Cell Membrane Single-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Proepiregulin Cleaved Into - Epiregulin antibody Anti-Epr antibody Anti-EREG antibody |
Information sourced from Uniprot.org