Anti-ERCC6L2 antibody (1262-1561) (STJ115110)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ERCC6L2 (1262-1561) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ERCC6L2 |
| Gene ID | 375748 |
| Uniprot ID | ER6L2_HUMAN |
| Immunogen Region | 1262-1561 |
| Immunogen Sequence | TSEERQKMLRDFYASQYPEV KEFFVDSVSQFNNSSFEKGE QRTRKKSDKRESLIKPRLSD SETLSFKDSTNKISQVCSLK TYKRKSVKFQNHISYREEVF FNDAETKKSPVSSTQEIDSG KNSQASEDTVTSRSLNSESE TRERRLENTMKDQQDLTRTG ISRKEPLLKLENKKIENPVL ENTSVISLLGDTSILDDLFK SHGNSPTQLPKKVLSGPMEK AKQRPKDFWDILNEQNDES |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1262-1561 of human ERCC6L2 (NP_064592.2). |
Additional Info
| Tissue Specificity | Expressed in bone marrow (at protein level). |
| Post Translational Modifications | Phosphorylated by NEK6. |
| Function | Promotes double-strand break (DSB) end-joining and facilitates programmed recombination by controlling how DNA ends are joined in a spatially oriented manner during repair. Also plays a role in DNA repair by restricting DNA end resection in double strand break (DSB) repair. Facilitates replication of complex DNA regions and regulates the maintenance of chromatin structure. |
| Protein Name | Dna Excision Repair Protein Ercc-6-Like 2Dna Repair And Recombination Protein Rad26-LikeExcision Repair Cross-Complementation Group 6-Like 2 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeMitochondrionChromosomeCentromereColocalizes With Nek6 In The CentrosomeIn Response To Dna DamageTranslocates From The Cytosol To Mitochondria And Nucleus In A Reactive Oxygen Species (Ros)-Dependent MannerCentromeric Localization Is Facilitated By Its Interaction With Pcna |
| Alternative Antibody Names | Anti-Dna Excision Repair Protein Ercc-6-Like 2 antibodyAnti-Dna Repair And Recombination Protein Rad26-Like antibodyAnti-Excision Repair Cross-Complementation Group 6-Like 2 antibodyAnti-ERCC6L2 antibodyAnti-C9orf102 antibodyAnti-RAD26L antibody |
Information sourced from Uniprot.org