Anti-ERCC1 antibody [SM4986] (STJA0004986)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenSynthesized peptide derived from human ERCC1
General Information
| Short Description | Mouse monoclonal anti-ERCC1 for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM4986 |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC/IF (H) 1:200-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | ERCC1 |
| Gene ID | 2067 |
| Uniprot ID | ERCC1_HUMAN |
| Immunogen | Synthesized peptide derived from human ERCC1 |
Additional Info
| Function | Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. Isoform 2: Not functional in the nucleotide excision repair pathway. Isoform 3: Not functional in the nucleotide excision repair pathway. Isoform 4: Not functional in the nucleotide excision repair pathway. |
| Protein Name | Dna Excision Repair Protein Ercc-1 |
| Database Links | Reactome: R-HSA-5685938Reactome: R-HSA-5696395Reactome: R-HSA-5696400Reactome: R-HSA-6782135Reactome: R-HSA-6783310 |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: CytoplasmNucleusIsoform 3: NucleusIsoform 4: Nucleus |
| Alternative Antibody Names | Anti-Dna Excision Repair Protein Ercc-1 antibodyAnti-ERCC1 antibody |
Information sourced from Uniprot.org