![Anti-ERBB3/HER3 nanobody [SAA1309] (STJN000171)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200784/412966/STJN000171-SDS-PAGE-1__86373.1749232493.jpg?c=1 "Anti-ERBB3/HER3 nanobody [SAA1309] (STJN000171)")
![Anti-ERBB3/HER3 nanobody [SAA1309] (STJN000171)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200784/412966/STJN000171-SDS-PAGE-1__86373.1749232493.jpg?c=1 "Anti-ERBB3/HER3 nanobody [SAA1309] (STJN000171)")
Anti-ERBB3/HER3 nanobody [SAA1309] (STJN000171)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Receptor Tyrosine-Protein Kinase Erbb-3 is suitable for use in ELISA, Flow Cytometry and SPR research applications. |
| Applications | ELISA/FC/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1309 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | ERBB3 |
| Gene ID | 2065 |
| Uniprot ID | ERBB3_HUMAN |
Additional Info
| Post Translational Modifications | Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. |
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it.ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. |
| Protein Name | Receptor Tyrosine-Protein Kinase Erbb-3Proto-Oncogene-Like Protein C-Erbb-3Tyrosine Kinase-Type Cell Surface Receptor Her3 |
| Database Links | Reactome: R-HSA-1227986 P21860-1Reactome: R-HSA-1236394 P21860-1Reactome: R-HSA-1250196 P21860-1Reactome: R-HSA-1257604 P21860-1Reactome: R-HSA-1306955 P21860-1Reactome: R-HSA-1358803 P21860-1Reactome: R-HSA-1963642 P21860-1Reactome: R-HSA-2219530 P21860-1Reactome: R-HSA-5673001 P21860-1Reactome: R-HSA-6785631 P21860-1Reactome: R-HSA-6811558 P21860-1Reactome: R-HSA-8847993 P21860-1Reactome: R-HSA-8863795 P21860-1Reactome: R-HSA-9664565 P21860-1Reactome: R-HSA-9665686 P21860-1 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Nanobody Names | Anti-Receptor Tyrosine-Protein Kinase Erbb-3 nanobodyAnti-Proto-Oncogene-Like Protein C-Erbb-3 nanobodyAnti-Tyrosine Kinase-Type Cell Surface Receptor Her3 nanobodyAnti-ERBB3 nanobodyAnti-HER3 nanobody |
Information sourced from Uniprot.org