Anti-ERBB3 antibody (1094-1111 aa) [R05-3F7] (STJA0012366)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human ErbB 3
General Information
| Short Description | Rabbit monoclonal anti-ErbB 3 (1094-1111 aa) for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-3F7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ERBB3 |
| Gene ID | 2065 |
| Uniprot ID | ERBB3_HUMAN |
| Immunogen | A synthetic peptide of human ErbB 3 |
| Immunogen Region | 1094-1111 aa |
Additional Info
| Tissue Specificity | Epithelial tissues and brain. |
| Post Translational Modifications | Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. |
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it.ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. |
| Protein Name | Receptor Tyrosine-Protein Kinase Erbb-3Proto-Oncogene-Like Protein C-Erbb-3Tyrosine Kinase-Type Cell Surface Receptor Her3 |
| Database Links | Reactome: R-HSA-1227986 P21860-1Reactome: R-HSA-1236394 P21860-1Reactome: R-HSA-1250196 P21860-1Reactome: R-HSA-1257604 P21860-1Reactome: R-HSA-1306955 P21860-1Reactome: R-HSA-1358803 P21860-1Reactome: R-HSA-1963642 P21860-1Reactome: R-HSA-2219530 P21860-1Reactome: R-HSA-5673001 P21860-1Reactome: R-HSA-6785631 P21860-1Reactome: R-HSA-6811558 P21860-1Reactome: R-HSA-8847993 P21860-1Reactome: R-HSA-8863795 P21860-1Reactome: R-HSA-9664565 P21860-1Reactome: R-HSA-9665686 P21860-1 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Receptor Tyrosine-Protein Kinase Erbb-3 antibodyAnti-Proto-Oncogene-Like Protein C-Erbb-3 antibodyAnti-Tyrosine Kinase-Type Cell Surface Receptor Her3 antibodyAnti-ERBB3 antibodyAnti-HER3 antibody |
Information sourced from Uniprot.org