| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERAP1 |
| Gene ID: | 51752 |
| Uniprot ID: | ERAP1_HUMAN |
| Immunogen Region: | 842-941 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 842-941 of human ERAP1 (Q9NZ08). |
| Immunogen Sequence: | NPVGYPLAWQFLRKNWNKLV QKFELGSSSIAHMVMGTTNQ FSTRTRLEEVKGFFSSLKEN GSQLRCVQQTIETIEENIGW MDKNFDKIRVWLQSEKLERM |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | N-glycosylated. |
| Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. |
| Protein Name | Endoplasmic Reticulum Aminopeptidase 1 Arts-1 Adipocyte-Derived Leucine Aminopeptidase A-Lap Aminopeptidase Pils Puromycin-Insensitive Leucyl-Specific Aminopeptidase Pils-Ap Type 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator |
| Database Links | Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Endoplasmic Reticulum Aminopeptidase 1 antibody Anti-Arts-1 antibody Anti-Adipocyte-Derived Leucine Aminopeptidase antibody Anti-A-Lap antibody Anti-Aminopeptidase Pils antibody Anti-Puromycin-Insensitive Leucyl-Specific Aminopeptidase antibody Anti-Pils-Ap antibody Anti-Type 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator antibody Anti-ERAP1 antibody Anti-APPILS antibody Anti-ARTS1 antibody Anti-KIAA0525 antibody Anti-UNQ584 antibody Anti-PRO1154 antibody |
Information sourced from Uniprot.org