Anti-Epoxide Hydrolase 1 antibody [R04-2F6] (STJA0035193)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human EPHX2
General Information
| Short Description | Rabbit monoclonal anti-Epoxide Hydrolase 1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-2F6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | EPHX2 |
| Gene ID | 2053 |
| Uniprot ID | HYES_HUMAN |
| Immunogen | A synthetic peptide of human EPHX2 |
Additional Info
| Post Translational Modifications | The N-terminus is blocked. The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (Probable). |
| Function | Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid. Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates. |
| Protein Name | Bifunctional Epoxide Hydrolase 2 Includes - Cytosolic Epoxide Hydrolase 2CehEpoxide HydrataseSoluble Epoxide HydrolaseSeh - Lipid-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-2142670Reactome: R-HSA-9018682Reactome: R-HSA-9033241 |
| Cellular Localisation | CytoplasmPeroxisome |
| Alternative Antibody Names | Anti-Bifunctional Epoxide Hydrolase 2 Includes - Cytosolic Epoxide Hydrolase 2 antibodyAnti-Ceh antibodyAnti-Epoxide Hydratase antibodyAnti-Soluble Epoxide Hydrolase antibodyAnti-Seh - Lipid-Phosphate Phosphatase antibodyAnti-EPHX2 antibody |
Information sourced from Uniprot.org