Anti-EPB41L4B/EHM2 antibody (Internal) (STJ71354)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-EPB41L4B/EHM2 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Preliminary experiments gave an approx 48kDa band in Human Brain (Hippocampus, Cerebellar Cortex, Cerebellum) and Human Bone Marrow lysates after 0.3µg/ml antibody staining. Please not |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | EPB41L4B |
| Gene ID | 54566 |
| Uniprot ID | E41LB_HUMAN |
| Accession Number | NP_060894.2; NP_061987.3 |
| Immunogen Region | Internal |
| Immunogen Sequence | HNYQPQYHPNIHPSQ |
| Specificity | This antibody is expected to recognise both reported isoforms (NP_060894.2; NP_061987.3). |
Additional Info
| Post Translational Modifications | May be negatively regulated by phosphorylation. |
| Function | Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18. Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing. May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation. |
| Protein Name | Band 4.1-Like Protein 4bErythrocyte Membrane Protein Band 4.1-Like 4bFerm-Containing Protein Cg1Protein Ehm2 |
| Cellular Localisation | CytoplasmCell JunctionTight JunctionAccumulates Along Apical Cell-Cell Boundaries And Is Also Detected In The Cytoplasm In A Punctate Manner |
| Alternative Antibody Names | Anti-Band 4.1-Like Protein 4b antibodyAnti-Erythrocyte Membrane Protein Band 4.1-Like 4b antibodyAnti-Ferm-Containing Protein Cg1 antibodyAnti-Protein Ehm2 antibodyAnti-EPB41L4B antibodyAnti-EHM2 antibodyAnti-LULU2 antibody |
Information sourced from Uniprot.org