Anti-ENTPD1 antibody (1-180) (STJ23545)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ENTPD1/CD39 (1-180) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ENTPD1 |
| Gene ID | 953 |
| Uniprot ID | ENTP1_HUMAN |
| Immunogen Region | 1-180 |
| Immunogen Sequence | MESEELADRVLDVVERSLSN YPFDFQGARIITGQEEGAYG WITINYLLGKFSQKTRWFSI VPYETNNQETFGALDLGGAS TQVTFVPQNQTIESPDNALQ FRLYGKDYNVYTHSFLCYGK DQALWQKLAKDIQVASNEIL RDPCFHPGYKKVVNVSDLYK TPCTKRFEMTLPFQQFEIQG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ENTPD1/CD39 (NP_001157655.1). |
Additional Info
| Tissue Specificity | Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Highly expressed in placenta, lung, skeletal muscle, kidney. |
| Post Translational Modifications | N-glycosylated. The N-terminus is blocked. Palmitoylated on Cys-13.which is required for caveola targeting. |
| Function | Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow. |
| Protein Name | Ectonucleoside Triphosphate Diphosphohydrolase 1Atp DiphosphohydrolaseAtp-DphAtpdaseEcto-Atp Diphosphohydrolase 1Ecto-Atpdase 1Ecto-Atpase 1Ecto-ApyraseLymphoid Cell Activation AntigenNucleoside Triphosphate Diphosphohydrolase 1Ntpdase1Cd Antigen Cd39 |
| Database Links | Reactome: R-HSA-8850843Reactome: R-HSA-9660826 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCaveola |
| Alternative Antibody Names | Anti-Ectonucleoside Triphosphate Diphosphohydrolase 1 antibodyAnti-Atp Diphosphohydrolase antibodyAnti-Atp-Dph antibodyAnti-Atpdase antibodyAnti-Ecto-Atp Diphosphohydrolase 1 antibodyAnti-Ecto-Atpdase 1 antibodyAnti-Ecto-Atpase 1 antibodyAnti-Ecto-Apyrase antibodyAnti-Lymphoid Cell Activation Antigen antibodyAnti-Nucleoside Triphosphate Diphosphohydrolase 1 antibodyAnti-Ntpdase1 antibodyAnti-Cd Antigen Cd39 antibodyAnti-ENTPD1 antibodyAnti-CD39 antibody |
Information sourced from Uniprot.org