Anti-ENSA antibody [R08-1G6] (STJA0034280)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human ENSA
General Information
| Short Description | Rabbit monoclonal anti-ENSA for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-1G6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ENSA |
| Gene ID | 2029 |
| Uniprot ID | ENSA_HUMAN |
| Immunogen | A synthetic peptide of human ENSA |
Additional Info
| Tissue Specificity | Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. |
| Post Translational Modifications | Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA. |
| Function | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. |
| Protein Name | Alpha-EndosulfineArpp-19e |
| Database Links | Reactome: R-HSA-2465910 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Alpha-Endosulfine antibodyAnti-Arpp-19e antibodyAnti-ENSA antibody |
Information sourced from Uniprot.org