Anti-Endothelin B receptor antibody (299-313 aa) (STJA0040932)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA peptide from human Endothelin B receptor (299-313 aa).
General Information
| Short Description | Rabbit polyclonal anti-Endothelin B receptor (299-313 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity-purified |
| Dilution Range | WB 1:1000-1:5000 |
| Formulation | PBS with 0.02% sodium azide. |
| Storage Instruction | Short term storage at 2-8°C for one week. At-20°C as an undiluted liquid for up to 12 months. |
Target Information
| Gene Symbol | EDNRB |
| Gene ID | 1910 |
| Uniprot ID | EDNRB_HUMAN |
| Immunogen | A peptide from human Endothelin B receptor (299-313 aa). |
| Immunogen Region | 299-313 aa |
| Immunogen Sequence | Human |
| Specificity | Antibody detects ETRB at 51 kDa in WB in mouse fetus protein lysate. A weaker band at approx 75 kDa may also be observed (unknown). Human, mouse, rat. |
Additional Info
| Tissue Specificity | Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. |
| Post Translational Modifications | Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405. |
| Function | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Name | Endothelin Receptor Type BEt-BEt-BrEndothelin Receptor Non-Selective Type |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-9856649 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalized After Activation By Endothelins |
| Alternative Antibody Names | Anti-Endothelin Receptor Type B antibodyAnti-Et-B antibodyAnti-Et-Br antibodyAnti-Endothelin Receptor Non-Selective Type antibodyAnti-EDNRB antibodyAnti-ETRB antibody |
Information sourced from Uniprot.org