Anti-ENAH/MENA antibody (710-760) {Biotin} (STJ506419)

SKU:
STJ506419-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ENAH/MENA (710-760) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 Mu g/Mu l
Dilution Range: ELISA 1:10, 000
IP 1:200
WB 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Enah
Gene ID: 13800
Uniprot ID: ENAH_MOUSE
Immunogen Region: 710-760
Immunogen: Synthetic peptide corresponding to amino acids within region 710-760 on mouse ENAH protein.
Tissue Specificity Expressed in heart and testis, lower levels in lung, skeletal muscle, kidney, pancreas and brain. Isoform 5 is expressed exclusively in the brain. Isoform 2 is expressed predominantly in brain, testis, ovary and fat. In the brain, isoforms 2 and 5 are expressed at highest levels in the hippocampus, cortex and midbrain, and at lowest levels in the striatum and cerebellum. Isoform 6 is expressed in brain and spleen.
Post Translational Modifications NTN1-induced PKA phosphorylation on Ser-255 directly parallels the formation of filopodial protrusions.
Function Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation.
Protein Name Protein Enabled Homolog
Npc-Derived Proline-Rich Protein 1
Ndpp-1
Database Links Reactome: R-MMU-376176
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Lamellipodium
Filopodium
Synapse
Cell Junction
Focal Adhesion
Targeted To The Leading Edge Of Lamellipodia And Filopodia By Mrl Family Members
Colocalizes At Filopodial Tips With A Number Of Other Proteins Including Vinculin And Zyxlin
Colocalizes With N-Wasp At The Leading Edge
Colocalizes With Gphn And Pfn At Synapses
Alternative Antibody Names Anti-Protein Enabled Homolog antibody
Anti-Npc-Derived Proline-Rich Protein 1 antibody
Anti-Ndpp-1 antibody
Anti-Enah antibody
Anti-Mena antibody
Anti-Ndpp1 antibody

Information sourced from Uniprot.org

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