| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ENAH/MENA (710-760) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5-1.5 Mu g/Mu l |
| Dilution Range: |
ELISA 1:10, 000IP 1:200WB 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Enah |
| Gene ID: |
13800 |
| Uniprot ID: |
ENAH_MOUSE |
| Immunogen Region: |
710-760 |
| Immunogen: |
Synthetic peptide corresponding to amino acids within region 710-760 on mouse ENAH protein. |
| Tissue Specificity | Expressed in heart and testis, lower levels in lung, skeletal muscle, kidney, pancreas and brain. Isoform 5 is expressed exclusively in the brain. Isoform 2 is expressed predominantly in brain, testis, ovary and fat. In the brain, isoforms 2 and 5 are expressed at highest levels in the hippocampus, cortex and midbrain, and at lowest levels in the striatum and cerebellum. Isoform 6 is expressed in brain and spleen. |
| Post Translational Modifications | NTN1-induced PKA phosphorylation on Ser-255 directly parallels the formation of filopodial protrusions. |
| Function | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation. |
| Protein Name | Protein Enabled HomologNpc-Derived Proline-Rich Protein 1Ndpp-1 |
| Database Links | Reactome: R-MMU-376176 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumFilopodiumSynapseCell JunctionFocal AdhesionTargeted To The Leading Edge Of Lamellipodia And Filopodia By Mrl Family MembersColocalizes At Filopodial Tips With A Number Of Other Proteins Including Vinculin And ZyxlinColocalizes With N-Wasp At The Leading EdgeColocalizes With Gphn And Pfn At Synapses |
| Alternative Antibody Names | Anti-Protein Enabled Homolog antibodyAnti-Npc-Derived Proline-Rich Protein 1 antibodyAnti-Ndpp-1 antibodyAnti-Enah antibodyAnti-Mena antibodyAnti-Ndpp1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
