Anti-EMC4 antibody (42-55 aa) [R08-6D5] (STJA0012063)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human TMEM85
General Information
| Short Description | Rabbit monoclonal anti-Transmembrane Protein 85 (42-55 aa) for use in WB and IP in Human, Mouse, Rat and Hamster samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Hamster |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-6D5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | EMC4 |
| Gene ID | 51234 |
| Uniprot ID | EMC4_HUMAN |
| Immunogen | A synthetic peptide of human TMEM85 |
| Immunogen Region | 42-55 aa |
Additional Info
| Tissue Specificity | Isoform 1 is expressed in brain and heart. Isoform 2 is expressed in heart. |
| Function | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). |
| Protein Name | Er Membrane Protein Complex Subunit 4Cell Proliferation-Inducing Gene 17 ProteinTransmembrane Protein 85 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCould Also Be A Single-Pass Transmembrane Protein With Cytosolic N-Terminus And Lumenal C-Terminus |
| Alternative Antibody Names | Anti-Er Membrane Protein Complex Subunit 4 antibodyAnti-Cell Proliferation-Inducing Gene 17 Protein antibodyAnti-Transmembrane Protein 85 antibodyAnti-EMC4 antibodyAnti-TMEM85 antibodyAnti-HSPC184 antibodyAnti-PIG17 antibody |
Information sourced from Uniprot.org