| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Elongation of very long chain fatty acids protein 5 (250-299 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ELOVL5 |
| Gene ID: | 60481 |
| Uniprot ID: | ELOV5_HUMAN |
| Immunogen Region: | 250-299 aa |
| Specificity: | ELOVL5 Polyclonal Antibody detects endogenous levels of ELOVL5 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ELOVL5 at the amino acid range 250-299 |
| Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid. |
| Protein Name | Very Long Chain Fatty Acid Elongase 5 3-Keto Acyl-Coa Synthase Elovl5 Elovl Fatty Acid Elongase 5 Elovl Fa Elongase 5 Elongation Of Very Long Chain Fatty Acids Protein 5 Fatty Acid Elongase 1 Helo1 Very Long Chain 3-Ketoacyl-Coa Synthase 5 Very Long Chain 3-Oxoacyl-Coa Synthase 5 |
| Database Links | Reactome: R-HSA-2046105 Reactome: R-HSA-2046106 Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Cell Projection Dendrite In Purkinje Cells The Protein Localizes To The Soma And Proximal Portion Of The Dendritic Tree |
| Alternative Antibody Names | Anti-Very Long Chain Fatty Acid Elongase 5 antibody Anti-3-Keto Acyl-Coa Synthase Elovl5 antibody Anti-Elovl Fatty Acid Elongase 5 antibody Anti-Elovl Fa Elongase 5 antibody Anti-Elongation Of Very Long Chain Fatty Acids Protein 5 antibody Anti-Fatty Acid Elongase 1 antibody Anti-Helo1 antibody Anti-Very Long Chain 3-Ketoacyl-Coa Synthase 5 antibody Anti-Very Long Chain 3-Oxoacyl-Coa Synthase 5 antibody Anti-ELOVL5 antibody Anti-ELOVL2 antibody Anti-PRO0530 antibody |
Information sourced from Uniprot.org