| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ELOVL5 (247-326) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ELOVL5 |
| Gene ID: |
60481 |
| Uniprot ID: |
ELOV5_HUMAN |
| Immunogen Region: |
247-326 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 247-326 of human ELOVL5 (NP_001229757.1). |
| Immunogen Sequence: |
GVIWPCTFPLGWLYFQIGYM ISLIALFTNFYIQTYNKKGA SRRKDHLKDHQNGSMAAVNG HTNSFSPLENNVKPRKLRKD |
| Tissue Specificity | Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum. |
| Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid. |
| Protein Name | Elongation Of Very Long Chain Fatty Acids Protein 53-Keto Acyl-Coa Synthase Elovl5Elovl Fatty Acid Elongase 5Elovl Fa Elongase 5Fatty Acid Elongase 1Helo1Very Long Chain 3-Ketoacyl-Coa Synthase 5Very Long Chain 3-Oxoacyl-Coa Synthase 5 |
| Database Links | Reactome: R-HSA-2046105Reactome: R-HSA-2046106Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell ProjectionDendriteIn Purkinje CellsThe Protein Localizes To The Soma And Proximal Portion Of The Dendritic Tree |
| Alternative Antibody Names | Anti-Elongation Of Very Long Chain Fatty Acids Protein 5 antibodyAnti-3-Keto Acyl-Coa Synthase Elovl5 antibodyAnti-Elovl Fatty Acid Elongase 5 antibodyAnti-Elovl Fa Elongase 5 antibodyAnti-Fatty Acid Elongase 1 antibodyAnti-Helo1 antibodyAnti-Very Long Chain 3-Ketoacyl-Coa Synthase 5 antibodyAnti-Very Long Chain 3-Oxoacyl-Coa Synthase 5 antibodyAnti-ELOVL5 antibodyAnti-ELOVL2 antibodyAnti-PRO0530 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
