Anti-ELMO1 antibody [R03-7M8] (STJA0036834)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human ELMO1
General Information
| Short Description | Rabbit monoclonal anti-ELMO1 for use in WB, ICC, IF, IP and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-7M8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:50FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ELMO1 |
| Gene ID | 9844 |
| Uniprot ID | ELMO1_HUMAN |
| Immunogen | A synthesized peptide derived from human ELMO1 |
Additional Info
| Tissue Specificity | Widely expressed, with a higher expression in the spleen and placenta. |
| Post Translational Modifications | Phosphorylated by HCK. |
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Protein Name | Engulfment And Cell Motility Protein 1Protein Ced-12 Homolog |
| Database Links | Reactome: R-HSA-164944Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCell MembraneTranslocation To Plasma Membrane Seems To Be Mediated By Dock1 And Crk |
| Alternative Antibody Names | Anti-Engulfment And Cell Motility Protein 1 antibodyAnti-Protein Ced-12 Homolog antibodyAnti-ELMO1 antibodyAnti-KIAA0281 antibody |
Information sourced from Uniprot.org