| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ELMO1 (527-727) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ELMO1 |
| Gene ID: |
9844 |
| Uniprot ID: |
ELMO1_HUMAN |
| Immunogen Region: |
527-727 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 527-727 of human ELMO1 (NP_055615.8). |
| Immunogen Sequence: |
DFQSRPILELKEKIQPEILE LIKQQRLNRLVEGTCFRKLN ARRRQDKFWYCRLSPNHKVL HYGDLEESPQGEVPHDSLQD KLPVADIKAVVTGKDCPHMK EKGALKQNKEVLELAFSILY DSNCQLNFIAPDKHEYCIWT DGLNALLGKDMMSDLTRNDL DTLLSMEIKLRLLDLENIQI PDAPPPIPKEPSNYDFVYDC N |
| Tissue Specificity | Widely expressed, with a higher expression in the spleen and placenta. |
| Post Translational Modifications | Phosphorylated by HCK. |
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Protein Name | Engulfment And Cell Motility Protein 1Protein Ced-12 Homolog |
| Database Links | Reactome: R-HSA-164944Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCell MembraneTranslocation To Plasma Membrane Seems To Be Mediated By Dock1 And Crk |
| Alternative Antibody Names | Anti-Engulfment And Cell Motility Protein 1 antibodyAnti-Protein Ced-12 Homolog antibodyAnti-ELMO1 antibodyAnti-KIAA0281 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
