| Function | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGAAT. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development. |
| Protein Name | Ets-Related Transcription Factor Elf-3E74-Like Factor 3Epithelial-Restricted With Serine BoxEpithelium-Restricted Ets Protein EsxEpithelium-Specific Ets Transcription Factor 1Ese-1 |
| Database Links | Reactome: R-HSA-1912408 |
| Cellular Localisation | CytoplasmNucleusLocalizes To The Cytoplasm Where It Has Been Shown To Transform Mcf-12a Mammary Epithelial Cells Via A Novel Cytoplasmic MechanismAlso Transiently Expressed And Localized To The Nucleus Where It Induces Apoptosis In Non-Transformed Breast Epithelial Cells Mcf-10a And Mcf-12a Via A Transcription-Dependent Mechanism |
| Alternative Antibody Names | Anti-Ets-Related Transcription Factor Elf-3 antibodyAnti-E74-Like Factor 3 antibodyAnti-Epithelial-Restricted With Serine Box antibodyAnti-Epithelium-Restricted Ets Protein Esx antibodyAnti-Epithelium-Specific Ets Transcription Factor 1 antibodyAnti-Ese-1 antibodyAnti-ELF3 antibodyAnti-ERT antibodyAnti-ESX antibodyAnti-JEN antibody |
Information sourced from Uniprot.org
