| Short Description : | Rabbit polyclonal ELAC2 (1-270) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ELAC2 |
| Gene ID: | 60528 |
| Uniprot ID: | RNZ2_HUMAN |
| Immunogen Region: | 1-270 |
| Immunogen Sequence: | MWALCSLLRSAAGRTMSQGR TISQAPARRERPRKDPLRHL RTREKRGPSGCSGGPNTVYL QVVAAGSRDSGAALYVFSEF NRYLFNCGEGVQRLMQEHKL KVARLDNIFLTRMHWSNVGG LSGMILTLKETGLPKCVLSG PPQLEKYLEAIKIFSGPLKG IELAVRPHSAPEYEDETMTV YQIPIHSEQRRGKHQPWQSP ERPLSRLSPERSSDSESNEN EPHLPHGVSQRRGVRDSSL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1). |
| Tissue Specificity | Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes. |
| Function | Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. |
| Protein Name | Zinc Phosphodiesterase Elac Protein 2Elac Homolog Protein 2Heredity Prostate Cancer Protein 2Ribonuclease Z 2Rnase Z 2Trna 3 Endonuclease 2Trnase Z 2 |
| Database Links | Reactome: R-HSA-6784531Reactome: R-HSA-6785470Reactome: R-HSA-8868766Reactome: R-HSA-9708296 |
| Cellular Localisation | MitochondrionMitochondrion MatrixMitochondrion NucleoidNucleusMainly Mitochondrial |
| Alternative Antibody Names | Anti-Zinc Phosphodiesterase Elac Protein 2 antibodyAnti-Elac Homolog Protein 2 antibodyAnti-Heredity Prostate Cancer Protein 2 antibodyAnti-Ribonuclease Z 2 antibodyAnti-Rnase Z 2 antibodyAnti-Trna 3 Endonuclease 2 antibodyAnti-Trnase Z 2 antibodyAnti-ELAC2 antibodyAnti-HPC2 antibody |
Information sourced from Uniprot.org
