Anti-eIF4A1 antibody [6D7-10D5-7H7] (STJA0032806)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenSynthetic Peptide of eIF4A1
General Information
| Short Description | Mouse monoclonal anti-eIF4A1 for use in WB, IHC-F, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-F/IHC-P/ICC/IF |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 6D7-10D5-7H7 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | EIF4A1 |
| Gene ID | 1973 |
| Uniprot ID | IF4A1_HUMAN |
| Immunogen | Synthetic Peptide of eIF4A1 |
Additional Info
| Function | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth. |
| Protein Name | Eukaryotic Initiation Factor 4a-IEif-4a-IEif4a-IAtp-Dependent Rna Helicase Eif4a-1 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-156827Reactome: R-HSA-429947Reactome: R-HSA-72649Reactome: R-HSA-72662Reactome: R-HSA-72702Reactome: R-HSA-72706Reactome: R-HSA-9820841Reactome: R-HSA-9820865 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell MembraneStress GranuleColocalizes With Pkp1 In Stress Granules Following Arsenate Or Hydrogen Peroxide Treatment |
| Alternative Antibody Names | Anti-Eukaryotic Initiation Factor 4a-I antibodyAnti-Eif-4a-I antibodyAnti-Eif4a-I antibodyAnti-Atp-Dependent Rna Helicase Eif4a-1 antibodyAnti-EIF4A1 antibodyAnti-DDX2A antibodyAnti-EIF4A antibody |
Information sourced from Uniprot.org