Anti-EIF3L antibody [R04-5C-5] (STJA0033141)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2Ak
ImmunogenPeptide
General Information
| Short Description | Mouse monoclonal anti-EIF3L for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-5C-5 |
| Isotype | IgG2Ak |
| Conjugation | Unconjugated |
| Purification | Protein G |
| Dilution Range | WB 1:2000-1:10000 |
| Formulation | Liquid in PBS, Glycerol and BSA |
| Storage Instruction | Store at-20°C. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | EIF3L |
| Gene ID | 51386 |
| Uniprot ID | EIF3L_HUMAN |
| Immunogen | Peptide |
Additional Info
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2. |
| Protein Name | Eukaryotic Translation Initiation Factor 3 Subunit LEif3lEukaryotic Translation Initiation Factor 3 Subunit 6-Interacting ProteinEukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-72649Reactome: R-HSA-72689Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 3 Subunit L antibodyAnti-Eif3l antibodyAnti-Eukaryotic Translation Initiation Factor 3 Subunit 6-Interacting Protein antibodyAnti-Eukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein antibodyAnti-EIF3L antibodyAnti-EIF3EIP antibodyAnti-EIF3S6IP antibodyAnti-HSPC021 antibodyAnti-HSPC025 antibodyAnti-MSTP005 antibody |
Information sourced from Uniprot.org