| Tissue Specificity | Ubiquitous, with the highest levels of expression in brain, testis and kidney. |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. |
| Protein Name | Eukaryotic Translation Initiation Factor 3 Subunit KEif3kEukaryotic Translation Initiation Factor 3 Subunit 12Muscle-Specific Gene M9 ProteinPlac-24Eif-3 P25Eif-3 P28 |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-72649Reactome: R-HSA-72689Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 3 Subunit K antibodyAnti-Eif3k antibodyAnti-Eukaryotic Translation Initiation Factor 3 Subunit 12 antibodyAnti-Muscle-Specific Gene M9 Protein antibodyAnti-Plac-24 antibodyAnti-Eif-3 P25 antibodyAnti-Eif-3 P28 antibodyAnti-EIF3K antibodyAnti-EIF3S12 antibodyAnti-ARG134 antibodyAnti-HSPC029 antibodyAnti-MSTP001 antibodyAnti-PTD001 antibody |
Information sourced from Uniprot.org
