Anti-EIF3G antibody (STJA0007452)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human EIF3G
General Information
| Short Description | Rabbit polyclonal anti-Eukaryotic translation initiation factor 3 subunit G for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EIF3G |
| Gene ID | 8666 |
| Uniprot ID | EIF3G_HUMAN |
| Immunogen | Synthesized peptide derived from human EIF3G |
| Specificity | This antibody detects endogenous levels of EIF3G at Human, Mouse, Rat |
Additional Info
| Function | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2. |
| Protein Name | Eukaryotic Translation Initiation Factor 3 Subunit GEif3gEukaryotic Translation Initiation Factor 3 Rna-Binding SubunitEif-3 Rna-Binding SubunitEukaryotic Translation Initiation Factor 3 Subunit 4Eif-3-DeltaEif3 P42Eif3 P44 |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-72649Reactome: R-HSA-72689Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706 |
| Cellular Localisation | CytoplasmNucleusPerinuclear RegionColocalizes With Aifm1 In The Nucleus And Perinuclear Region |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 3 Subunit G antibodyAnti-Eif3g antibodyAnti-Eukaryotic Translation Initiation Factor 3 Rna-Binding Subunit antibodyAnti-Eif-3 Rna-Binding Subunit antibodyAnti-Eukaryotic Translation Initiation Factor 3 Subunit 4 antibodyAnti-Eif-3-Delta antibodyAnti-Eif3 P42 antibodyAnti-Eif3 P44 antibodyAnti-EIF3G antibodyAnti-EIF3S4 antibody |
Information sourced from Uniprot.org