| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EIF2S3 (173-472) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EIF2S3 |
| Gene ID: |
1968 |
| Uniprot ID: |
IF2G_HUMAN |
| Immunogen Region: |
173-472 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 173-472 of human EIF2S3 (NP_001406.1). |
| Immunogen Sequence: |
HLAAIEIMKLKHILILQNKI DLVKESQAKEQYEQILAFVQ GTVAEGAPIIPISAQLKYNI EVVCEYIVKKIPVPPRDFTS EPRLIVIRSFDVNKPGCEVD DLKGGVAGGSILKGVLKVGQ EIEVRPGIVSKDSEGKLMCK PIFSKIVSLFAEHNDLQYAA PGGLIGVGTKIDPTLCRADR MVGQVLGAVGALPEIFTELE ISYFLLRRLLGVRTEGDKKA AKVQKLSKNEVLMVNIGSL |
| Tissue Specificity | Expressed in testis, brain, liver and muscle. |
| Function | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
| Protein Name | Eukaryotic Translation Initiation Factor 2 Subunit 3Eukaryotic Translation Initiation Factor 2 Subunit Gamma XEif-2-Gamma XEif-2gx |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-381042Reactome: R-HSA-382556Reactome: R-HSA-72649Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706Reactome: R-HSA-72731Reactome: R-HSA-9633012Reactome: R-HSA-9648895 |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 2 Subunit 3 antibodyAnti-Eukaryotic Translation Initiation Factor 2 Subunit Gamma X antibodyAnti-Eif-2-Gamma X antibodyAnti-Eif-2gx antibodyAnti-EIF2S3 antibodyAnti-EIF2G antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
