| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EIF2B3 |
| Gene ID: | 8891 |
| Uniprot ID: | EI2BG_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human EIF2B3 (NP_065098.1). |
| Immunogen Sequence: | MEFQAVVMAVGGGSRMTDLT SSIPKPLLPVGNKPLIWYPL NLLERVGFEEVIVVTTRDVQ KALCAEFKMKMKPDIVCIPD DADMGTADSLRYIYPKLKTD VLVLSCDLITDVALHEVVDL FRAYDASLAMLMRKGQDSIE PVPGQKGKKKAVEQRDFIGV DSTGKRLLFMANEADLDEEL VIKGSILQKHPRIRFHTGLV DAHLYCLKKYIVDFLMENGS ITSIRSELIPYLVRKQFSS |
| Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. |
| Protein Name | Translation Initiation Factor Eif2b Subunit GammaEif2b Gdp-Gtp Exchange Factor Subunit Gamma |
| Database Links | Reactome: R-HSA-72731 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Translation Initiation Factor Eif2b Subunit Gamma antibodyAnti-Eif2b Gdp-Gtp Exchange Factor Subunit Gamma antibodyAnti-EIF2B3 antibody |
Information sourced from Uniprot.org