Anti-EIF2B2 antibody (1-120) (STJ29107)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal EIF2B2 (1-120) antibody for use in WB, IHC-P, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specif |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EIF2B2 |
| Gene ID | 8892 |
| Uniprot ID | EI2BB_HUMAN |
| Immunogen Region | 1-120 |
| Immunogen Sequence | MPGSAAKGSELSERIESFVE TLKRGGGPRSSEEMARETLG LLRQIITDHRWSNAGELMEL IRREGRRMTAAQPSETTVGN MVRRVLKIIREEYGRLHGRS DESDQQESLHKLLTSGGLNE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human EIF2B2 (NP_055054.1). |
Additional Info
| Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. |
| Protein Name | Translation Initiation Factor Eif2b Subunit BetaS20i15S20iii15Eif2b Gdp-Gtp Exchange Factor Subunit Beta |
| Database Links | Reactome: R-HSA-72731 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Translation Initiation Factor Eif2b Subunit Beta antibodyAnti-S20i15 antibodyAnti-S20iii15 antibodyAnti-Eif2b Gdp-Gtp Exchange Factor Subunit Beta antibodyAnti-EIF2B2 antibodyAnti-EIF2BB antibody |
Information sourced from Uniprot.org