Anti-EFNB3 antibody (221-270 aa) (STJ92961)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human EFNB3 at the amino acid range 221-270
General Information
| Short Description | Rabbit polyclonal anti-Ephrin-B3 (221-270 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EFNB3 |
| Gene ID | 1949 |
| Uniprot ID | EFNB3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human EFNB3 at the amino acid range 221-270 |
| Immunogen Region | 221-270 aa |
| Specificity | Ephrin-B3 Polyclonal Antibody detects endogenous levels of Ephrin-B3 protein. |
Additional Info
| Function | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for nipah virus and hendra virus. |
| Protein Name | Ephrin-B3Eph-Related Receptor Transmembrane Ligand Elk-L3Eph-Related Receptor Tyrosine Kinase Ligand 8Lerk-8 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928662Reactome: R-HSA-3928664Reactome: R-HSA-3928665 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Ephrin-B3 antibodyAnti-Eph-Related Receptor Transmembrane Ligand Elk-L3 antibodyAnti-Eph-Related Receptor Tyrosine Kinase Ligand 8 antibodyAnti-Lerk-8 antibodyAnti-EFNB3 antibodyAnti-EPLG8 antibodyAnti-LERK8 antibody |
Information sourced from Uniprot.org