| Post Translational Modifications | Methylated. Binding to histone H1 'Lys-26' promotes mono-, di-, and trimethylation of internal lysines. |
| Function | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
| Protein Name | Polycomb Protein EedHeedEmbryonic Ectoderm Development ProteinWd Protein Associating With Integrin Cytoplasmic Tails 1Wait-1 |
| Database Links | Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214841Reactome: R-HSA-5617472Reactome: R-HSA-8943724Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9710421 |
| Cellular Localisation | NucleusChromosomeTransiently Colocalizes With Xist At Inactive X Chromosomes |
| Alternative Antibody Names | Anti-Polycomb Protein Eed antibodyAnti-Heed antibodyAnti-Embryonic Ectoderm Development Protein antibodyAnti-Wd Protein Associating With Integrin Cytoplasmic Tails 1 antibodyAnti-Wait-1 antibodyAnti-EED antibody |
Information sourced from Uniprot.org
