• STJ70352 (4µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. These results could not be obtained after antigen retrieval at pH6.

Anti-EDD1/HYD antibody (C-Term) (STJ70352)

SKU:
STJ70352-100

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Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse/Rat/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-EDD1/HYD (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-1-2µg/ml, 1-2µg/ml
ELISA-antibody detection limit dilution 1:4000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: UBR5
Gene ID: 51366
Uniprot ID: UBR5_HUMAN
Immunogen Region: C-Term
Accession Number: NP_056986.2
Immunogen Sequence: LAIKTKNFGFV
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Protein Name E3 Ubiquitin-Protein Ligase Ubr5
E3 Ubiquitin-Protein Ligase - Hect Domain-Containing 1
Hect-Type E3 Ubiquitin Transferase Ubr5
Hyperplastic Discs Protein Homolog
Hhyd
Progestin-Induced Protein
Cellular Localisation Nucleus
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Ubr5 antibody
Anti-E3 Ubiquitin-Protein Ligase - Hect Domain-Containing 1 antibody
Anti-Hect-Type E3 Ubiquitin Transferase Ubr5 antibody
Anti-Hyperplastic Discs Protein Homolog antibody
Anti-Hhyd antibody
Anti-Progestin-Induced Protein antibody
Anti-UBR5 antibody
Anti-EDD antibody
Anti-EDD1 antibody
Anti-HYD antibody
Anti-KIAA0896 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance