Anti-EDARADD antibody (1-215) (STJ118396)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal EDARADD (1-215) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EDARADD |
| Gene ID | 128178 |
| Uniprot ID | EDAD_HUMAN |
| Immunogen Region | 1-215 |
| Immunogen Sequence | MGLRTTKQMGRGTKAPGHQE DHMVKEPVEDTDPSTLSFNM SDKYPIQDTELPKAEECDTI TLNCPRNSDMKNQGEENGFP DSTGDPLPEISKDNSCKENC TCSSCLLRAPTISDLLNDQD LLDVIRIKLDPCHPTVKNWR NFASKWGMSYDELCFLEQRP QSPTLEFLLRNSQRTVGQLM ELCRLYHRADVEKVLRRWVD EEWPKRERGDPSRHF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human EDARADD (NP_665860.2). |
Additional Info
| Tissue Specificity | Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis. |
| Function | Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B. |
| Protein Name | Ectodysplasin-A Receptor-Associated Adapter ProteinEdar-Associated Death Domain ProteinProtein Crinkled Homolog |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ectodysplasin-A Receptor-Associated Adapter Protein antibodyAnti-Edar-Associated Death Domain Protein antibodyAnti-Protein Crinkled Homolog antibodyAnti-EDARADD antibody |
Information sourced from Uniprot.org