Anti-ECD antibody (236-286 aa) (STJ198327)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SGT1/ECD at the amino acid range 236-286
General Information
| Short Description | Rabbit polyclonal anti-Protein ecdysoneless homolog (236-286 aa) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ECD |
| Gene ID | 11319 |
| Uniprot ID | ECD_HUMAN |
| Immunogen | Synthesized peptide derived from the human SGT1/ECD at the amino acid range 236-286 |
| Immunogen Region | 236-286 aa |
| Specificity | This antibody detects endogenous levels of SGT1/ECD at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated predominantly by CK2 on two serine-containing clusters.involved in cell cycle regulation activity. |
| Function | Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing. Participates together with DDX39A in mRNA nuclear export. |
| Protein Name | Protein Ecdysoneless HomologHuman Suppressor Of Gcr TwoHsgt1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusPredominantly Is Located In The Cytoplasm |
| Alternative Antibody Names | Anti-Protein Ecdysoneless Homolog antibodyAnti-Human Suppressor Of Gcr Two antibodyAnti-Hsgt1 antibodyAnti-ECD antibody |
Information sourced from Uniprot.org