| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein ecdysoneless homolog (236-286 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ECD |
| Gene ID: |
11319 |
| Uniprot ID: |
ECD_HUMAN |
| Immunogen Region: |
236-286 aa |
| Specificity: |
This antibody detects endogenous levels of SGT1/ECD at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from the human SGT1/ECD at the amino acid range 236-286 |
| Post Translational Modifications | Phosphorylated predominantly by CK2 on two serine-containing clusters.involved in cell cycle regulation activity. |
| Function | Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing. |
| Protein Name | Protein Ecdysoneless HomologHuman Suppressor Of Gcr TwoHsgt1 |
| Cellular Localisation | CytoplasmNucleusPredominantly Is Located In The Cytoplasm |
| Alternative Antibody Names | Anti-Protein Ecdysoneless Homolog antibodyAnti-Human Suppressor Of Gcr Two antibodyAnti-Hsgt1 antibodyAnti-ECD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
