Anti-EBI3 antibody [R01-8M8] (STJA0037285)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human EBI3
General Information
| Short Description | Rabbit monoclonal anti-EBI3 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-8M8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | EBI3 |
| Gene ID | 10148 |
| Uniprot ID | IL27B_HUMAN |
| Immunogen | A synthesized peptide derived from human EBI3 |
Additional Info
| Function | Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. |
| Protein Name | Interleukin-27 Subunit BetaIl-27 Subunit BetaIl-27bEpstein-Barr Virus-Induced Gene 3 ProteinEbv-Induced Gene 3 Protein |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020956 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-27 Subunit Beta antibodyAnti-Il-27 Subunit Beta antibodyAnti-Il-27b antibodyAnti-Epstein-Barr Virus-Induced Gene 3 Protein antibodyAnti-Ebv-Induced Gene 3 Protein antibodyAnti-EBI3 antibodyAnti-IL27B antibody |
Information sourced from Uniprot.org