Anti-EBI3 antibody (130-229) [S2MR] (STJ11103052)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal EBI3 (130-229) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EBI3 |
| Gene ID | 10148 |
| Uniprot ID | IL27B_HUMAN |
| Immunogen Region | 130-229 |
| Immunogen Sequence | DPPEGVRLSPLAERQLQVQW EPPGSWPFPEIFSLKYWIRY KRQGAARFHRVGPIEATSFI LRAVRPRARYYVQVAAQDLT DYGELSDWSLPATATMSLGK |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 130-229 of human EBI3 (Q14213). |
Additional Info
| Function | Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. |
| Protein Name | Interleukin-27 Subunit BetaIl-27 Subunit BetaIl-27bEpstein-Barr Virus-Induced Gene 3 ProteinEbv-Induced Gene 3 Protein |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020956 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-27 Subunit Beta antibodyAnti-Il-27 Subunit Beta antibodyAnti-Il-27b antibodyAnti-Epstein-Barr Virus-Induced Gene 3 Protein antibodyAnti-Ebv-Induced Gene 3 Protein antibodyAnti-EBI3 antibodyAnti-IL27B antibody |
Information sourced from Uniprot.org