Anti-EBF1 antibody [R04-7K9] (STJA0036927)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human EBF1
General Information
| Short Description | Rabbit monoclonal anti-EBF1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-7K9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | EBF1 |
| Gene ID | 1879 |
| Uniprot ID | COE1_HUMAN |
| Immunogen | A synthesized peptide derived from human EBF1 |
Additional Info
| Function | Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold. (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells. In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency. |
| Protein Name | Transcription Factor Coe1O/E-1Oe-1Early B-Cell Factor |
| Database Links | Reactome: R-HSA-381340Reactome: R-HSA-9752946 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Coe1 antibodyAnti-O/E-1 antibodyAnti-Oe-1 antibodyAnti-Early B-Cell Factor antibodyAnti-EBF1 antibodyAnti-COE1 antibodyAnti-EBF antibody |
Information sourced from Uniprot.org