| Function | Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold. (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells. In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency. |
| Protein Name | Transcription Factor Coe1O/E-1Oe-1Early B-Cell Factor |
| Database Links | Reactome: R-HSA-381340Reactome: R-HSA-9752946 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Coe1 antibodyAnti-O/E-1 antibodyAnti-Oe-1 antibodyAnti-Early B-Cell Factor antibodyAnti-EBF1 antibodyAnti-COE1 antibodyAnti-EBF antibody |
Information sourced from Uniprot.org
