| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EBF1 (500-591) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EBF1 |
| Gene ID: |
1879 |
| Uniprot ID: |
COE1_HUMAN |
| Immunogen Region: |
500-591 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 500-591 of human EBF1 (NP_076870.1). |
| Immunogen Sequence: |
GGSPTFLNGSAANSPYAIVP SSPTMASSTSLPSNCSSSSG IFSFSPANMVSAVKQKSAFA PVVRPQTSPPPTCTSTNGNS LQAISGMIVPPM |
| Function | Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold. (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells. In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency. |
| Protein Name | Transcription Factor Coe1O/E-1Oe-1Early B-Cell Factor |
| Database Links | Reactome: R-HSA-381340Reactome: R-HSA-9752946 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Coe1 antibodyAnti-O/E-1 antibodyAnti-Oe-1 antibodyAnti-Early B-Cell Factor antibodyAnti-EBF1 antibodyAnti-COE1 antibodyAnti-EBF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
